Curcumin in Prostate cancer

Turmeric, also called curcumin, has been used in Asian cuisine for thousands of years. Powder ground from the dried root is an element in curry. Turmeric is one of the cheaper spices and makes a vivid spatter of colour, so it gets heaped into low-market curry blends as fill. Turmeric clutches a high place in Ayurvedic medicine as a "cleanser of the body" and today science is finding a growing list of unhealthy conditions which turmeric's active ingredient heals. Broad interest in curcumin's anti-inflammatory effects is increasing.

Researchers are examining curcumin as a possible immune system stimulator that can modulate the activation of T cells, B cells, macrophages, neutrophils, natural killer cells, and dendritic cells; down regulate various pro-inflammatory cytokines and chemokines, and enhance antibody responses. This activity, some researchers write that curcumin's reported beneficial effects in arthritis, allergy, asthma, atherosclerosis, heart disease, Alzheimer's disease, diabetes, and cancer might be due in part to its ability to adapt the immune system. Together, these findings warrant further consideration of curcumin as a therapy for immune disorders.

Today curcumin is on a margin between ancient food customs and cutting-edge medicine. In suburban cuisine it can brighten and glorify nutritious foods (cauliflower, white fish). At ballpark, beach and food mall a dab of "hidden" curcumin helps carnivore bellies lower risks from gorging on over-handled broiled oddments. In Asia the root and powder are used in cooking, home remedies and medicine: to gild and help preserve festive dishes and in drinks, ointments and poultices to treat sore throat, sprains, inflammation and wounds. In the lab, scientists are dosing rats with curcumin to measure its effects on cancer.

Turmeric lore in recent decades drifted outwards from Asian diaspora communities in European cities like Leicester, UK. Local researchers and cancer patients listened up. Clusters of men on Internet prostate cancer support groups (notably Don Cooley's lists) began seriously experimenting with turmeric to cope with a troublesome side-effect of androgen-suppression therapy, gynecomastia (sore swollen breasts). Most men who take antiandrogen drugs like Flutamide (Eulexin) or Casodex experience this breast swelling, which can be painful. Gynecomastia can occur also with use of finasteride (Proscar), prescribed for BPH (benign growth of the prostate) and now under discussion as a chemo-preventive for prostate cancer. Before starting Casodex some patients opt to receive a brief course of radiation to the breasts. Others have tried low-dose tamoxifen, which raises levels of circulating estradiol. Then there are the turmeric warriors, who report that dietary intake of turmeric (in salads, soups and sandwiches made with fresh root) and use of curcumin paste externally brings some relief.

Still more mysteriously, University of Leicester began investigating dietary agents including curcumin, genistein, and the vitamin A analogue 13-cis retinoic acid for tumour-suppressing properties. Antioxidant, anti-inflammatory and anti-carcinogenic properties of turmeric and curcumin are undergoing intense research. Several studies point towards that curcumin slows the development and growth of a number of types of cancer cells. In Japan this year researchers defined curcumin as a broad-spectrum anti-cancer agent. Its induction of “detoxifying enzymes,” the researchers say, indicates its "potential value, as a protective agent against chemical carcinogenesis and other forms of electrophilic toxicity. The significance of these results can be implicated in relation to cancer chemopreventive effects of curcumin against the induction of tumours in various target organs." Some researchers say curcumin inhibits angiogenesis, i.e. formation of new blood vessels, which tumours use to nourish themselves as they spread. For cancer patients, until curcumin has been shown in well-designed, well-conducted human clinical trials to have measurable effects on existing disease, it remains just another interesting home remedy with a lot of guarantee.

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