Role of Curcumin in inflammation

Inflammation is a double-edged sword. When you have a cut or other wound, it can be a strong defence. But chronic, so-called “deregulated” inflammation can increase disease risk. Research shows curcumin acts as a forager of nitric oxide and inhibits COX-2, a pro-inflammatory substance. Also a potent forager of superoxide, the anti-inflammatory activity and superoxide scavenging property of curcumin are proven correlated. Clinically, curcumin has worked as well as cortisone or phenylbutazone for rheumatoid arthritis, osteoarthritis and post-operative inflammation.

Curcumin has similar anti-inflammatory action as NSAIDS, but without side effects. Contrasting aspirin and other classical COX-inhibitors, curcumin selectively inhibits synthesis of inflammatory prostaglandin thromboxane without affecting prostacyclin synthesis, and curcumin thereby protects against vascular thrombosis.

COX-inhibitors and NSAIDS have hazardous side-effects; COX-2 inhibitors are required to include black-box warnings. Curcumin is safe, even at doses up to 8,000 mg per day. Curcumin also reduces COXs better than indomethacin, a currently prescribed mixed COX inhibitor.

A double-blind crossover study in patients with "definite" rheumatoid arthritis compared the antirheumatic activity of curcumin (1200 mg/day) with phenylbutazone, a corticosteroids drug (300 mg/day). The curcumin therapy resulted in "significant" improvements over corticosteroids. Curcumin better relieved morning stiffness and joint swelling, and improved walking time. Best of all, curcumin was well-tolerated and produced no side-effects.

Another available study found curcumin significantly suppresses systemic inflammation markers MMP-3 by 48% to 99%, and MMP-13 by 45% to 97%. Researchers concluded curcumin could be useful for reducing cartilage deprivation (resorption by MMPs) in arthritis. Unfortunately, pure curcumin (including all known curcuminoids) is very poorly absorbed into your bloodstream after oral ingestion due to rapid metabolism in the liver and intestinal wall, and rapid systemic elimination.

Until recently, extremely high doses of curcumin were required to obtain desired blood levels. Scientists have long sought a more bioavailable form of curcumin to maximize curcumin's efficacy. In fact, most consumers may not realize many research studies achieved effective blood levels of curcumin by intravenous injections--directly into the veins. While it may be available in other parts of the world, injectable forms of curcumin are not sold in the United States. Curcumin provides curcumin blood levels up to 800% greater than other standardized 95% curcumin and 637% greater bioavailability than curcumin blended with piperine and lecithin.

The good information is a new, patent-pending curcumin product dramatically increases blood plasma curcumin to levels not previously seen through oral supplementation. (This impressive rise in bioavailability is achieved without piperine.) The new curcumin relies upon a specific ratio of curcuminoids reconstituted with a high content of sesquiterpenoids (turmeric essential oil compounds).

PRODUCT

OUR CURCUMIN CAPSULES

Planet Ayurveda Curcumin gives the best results than the other similar supplements from other companies. The reason is that we use standardized 500 mg extract of curcumin containing 95 % curcuminoids in pure vegetarian capsule shells.

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Each Bottle contains

60 Vegi Capsules