Curcumin for Alzheimer's disease

One of the most exhilarating areas of curcumin research occupies its effects on the brain. Alzheimer’s disease and dementia are two of the most feared conditions associated with aging. Currently, there aren’t any truly successful conventional treatments that help reverse the consequences of these brain disorders. Perhaps that’s why scientists are working so hard to determine whether turmeric components may be part of the answer to making serious strides in this arena.

But a major obstacle occurs for investigating curcumin. Decades worth of research point towards that this probable super herb has relatively poor bioavailability. Test tube researches disclose consistently positive results, but it’s just not absorbed very well by the body. Fortunately, newly developed forms of this herbal extract come into view to evade this problem.

A 2008 study published in the Journal of Clinical Psychopharmacology examined the effects of either 1 or 4 grams of specially processed curcumin in 22 Alzheimer’s patients over a 6 month period. The turmeric extract used in this research is known as BCM-95 and has been shown to increase the bioavailability of curcumin several-fold over other formerly tested turmeric extracts. Abeta plaque deposits are believed to be a major factor in the formation of the disease. It was concluded that the curcumin encouraged a release of Abeta from the brain and into the bloodstream. A boost in vitamin E was also eminent. Some evidence suggests that vitamin E may also benefit those at risk for Alzheimer’s disease.

Many other current trials imply that curcumin has a multi-modal impact on AD and various dementia models. One boulevard of research is the role that it plays in skirmishing oxidative harm caused by heavy metals in the brain, such as aluminium and iron. Countering the detrimental effects of heavy metal toxicity has been exposed to get better memory preservation and slow the aging process of the brain in quite a lot of animal examinations.

The battle against cancer is perhaps an even more promising aspect of turmeric research. A group of rats that were fed with curcumin, in addition to Hormonal Replacement Therapy, showed a delay in breast tumour growth, fewer total tumours and undesirable changes to breast tissue. A test tube experiment conducted on human breast cells also supports these current findings.
Together, these experiments direct to alterations in cell communication and genetic expression that discourage cancer cell growth and spread. Perhaps the most positive of these findings is that turmeric consistently shows an ability to selectively kill tumour cells while leaving healthy cells intact.

Alzheimer’s disease/dementia and cancer may garner most of the headlines, but there’s a lot more going on in the world of curcumin research. Like:

• Digestive strength: The effects of IBD generally comprise of abdominal pain, diarrhoea, fatigue, indigestion, intestinal damage and weight loss. It appears that curcumin modulates the immune system so that it won’t inappropriately attack the lining of the intestines. Recent evidence also suggests that turmeric may help combat unwanted bacteria, such as the cancer and ulcer causing H. pylori bug, and improve the transit of food through the digestive system.

• Multiple Sclerosis – Multiple Sclerosis is an autoimmune condition that impairs the ability of nerve cells in the brain and spinal cord from properly communicating with each other. Symptoms of this miscommunication can include fatigue, muscle stiffness and weakness, numbness or pain, poor balance and coordination and vision problems. The good news is that preliminary evidence suggests that curcumin may halt or even reverse a form of Multiple Sclerosis in mice (known as “autoimmune encephalomyelitis”). It’s also been noted that countries that often eat turmeric rich meals have a much lower incidence of Multiple Sclerosis. Finally; anxiety is thought to be an exacerbating factor in Multiple Sclerosis progression. Curcumin extracts may play a role in blunting the effects of chronic stress.

The future of curcumin research appears very bright and progressive as well. Some of the most hopeful trials recently have tested the synergistic pairing of curcumin with resveratrol (the “red wine molecule”) vs. cancer and as an addiction and obesity fighter. That same combination is showing great progress towards prostate cancer and prevention as well. Two different blends of a) curcumin and fish oil; and b) vitamin D and curcumin are also generating buzz in the quest for a viable Alzheimer’s cure. Only time will tell whether these or other natural ingredient blends will provide results that are even greater than the sum of their parts.
The fact is that most of the trials listed here and elsewhere have been performed in diseased animal models or in test tube studies. But the few human studies that have been completed are positive adequate to make curcumin one of the most widely studied, used and researched herb in modern medicine. There is a genuine reason for all the stimulation in both the natural and pharmaceutical sectors.

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